Explaining the technology
Innovative Solutions, Long-Lasting Results: Explore Hallura's Cutting-Edge Technology
Pioneering HA Fillers Excellence: Crafting Innovations to Shape the Future of Beauty.
Hallura offers a new horizon of aesthetic medicine that is safe, innovative, and natural. Our cutting-edge technology, coupled with our team’s expertise, provides you with personalized treatments and long-lasting results.
Our
Revolutionary
Technology:
BioLinkMatrix
At Hallura, we’ve redefined the landscape of hyaluronic acid (HA) dermal fillers through our groundbreaking technology known as BioLinkMatrix. This innovative approach represents a significant leap forward in the field of aesthetic medicine, offering a unique solution for those seeking natural, safe, and long-lasting results.
With a foundation rooted in successful clinical trials and a steadfast commitment to natural beauty, safety, and effectiveness, Hallura’s BioLinkMatrix emerges as a guiding light for individuals seeking personalized, adaptive, and confidence-boosting aesthetic treatments.
WE ARE
FILLERS HA
BASED ON THE 2023 NOBEL PRIZE IN CHEMISTRY
FIRST TIME INTRODUCED TO THE AESTHETIC FIELD
BASED ON THE 2023 NOBEL PRIZE IN CHEMISTRY
FIRST TIME INTRODUCED TO THE AESTHETIC FIELD
WHY HALLURA?
The breakthrough technology utilized by Hallura® sets it apart as innovative and revolutinary compared to existing technologies in the market, both in terms of production, safety, and the user experience of healthcare professionals ultilizing Hallura’s products.
Dr. Elzbieta Kowalska-Oledzka, Warsaw, Poland
Dr. Rodrigo da Mota, Düsseldorf, Germany
Good tolerance from subject's self assessments
Very good tolerance to Halluras™ range, with lower, more transient and less severe site reaction reported by the subject treatment, compared to market leaders’s data.
HALLURA® European Clinical Study (19E2031) on 132 patients for Lips enhancement, NLF correction and Cheeks enhancement. Compared to FDA, pivotal studies data data on Market leaders. Patients self assesment within 14-days Injection Site Reactions diary, reaction lasting more than 8 days (#) No reported data.
The Revolution
While All HA fillers are crosslinked, Hallura developed BiOLinkMatrix “lock-key” cross-linking, perfectly elastic compared to current HA in the market.
Current HA
- Damaging the HA polymer chains
- Losing elasticity
- Granular, harder materials
BioLinkMatrix
- Sustaining the long polymer chains
- Pure Elasticity
- Granular, harder materials
- Natural and Youthful look.
LONG-LAStING RESULT'S
lONG-lASTING RESULTS
The Hallura Advantage in three steps
Our Journey began with a commitment to creating dermal fillers that not only meet but exceed the expectations of individuals seeking aesthetics treatments.
Sustaining the long polymer chains
Hallura employs BioLinkMatrix, inspired by the 2023 Nobel Prize-winning Click Chemistry. This technology enables precise, minimal modification of native Hyaluronic Acid (HA) polymer through bio-orthogonal cross-linking.
The preserved natural HA chains are crucial for maintaining youthful skin properties, ensuring effective skin rejuvenation.
Bio Stimulation of Collagen 1 and 3 and Elastin
Utilizing a distinctive method, Hallura fosters targeted bio-stimulation, promoting the production of collagen types 1 and 3 along with elastin.
This cutting-edge technology positions Hallura as a leader in delivering effective solutions for skin rejuvenation.
Natural and long-lasting results
Hallura’s products closely mimic youthful skin by preserving the natural properties of the HA biopolymer and minimizing side reactions. The gel’s adaptive elasticity integrates seamlessly, promoting bio-stimulation for a lasting, natural appearance.
This emphasis on safety and natural outcomes through bio-orthogonal chemistry distinguishes Hallura from competitors using harsh cross-linking methods in the dermal fillers market.
CLINICAL STUDY HIGHLIGHTS
Efficacy and duration of Halluras®’s targeted portfolio
Clinical study's
outcome
- Formal formulations, 3 indications.
- Primary endpoints passed with statistical significance. Widely above the 60% sucess threshold.
- Secondary endpoints demonstrate effectiveness over study duration of 18 months (clear indication of durability over 15 months).
- Safety data demonstrate a strong safety profile of each of the products.
Hallura® praised1 for natural results and sensations
Formal formulations, 3 indications.
“Very good tissue integration: it looks like tissue is thickening. You don’t feel the the filler underneath the skin as usually. Tissue and filler become one.”
“Predictability. Super-forgiving product.”
“What you see is what you get.”
“More than excellent. Never had this experience in the lips witth any product on the market.”
Note Assessed by clinical study stakeholders
ELASTICITY &
BIOSTIMULATION
effectively more elastin and collagen new produce gels HLR by stimulated Fibroblasts
Human fibroblast culture in presence of HLR-2
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Regeneration of young and high quality. Collagen:
+20% Collagen type III - High levels of Elastin: +75 Elastin
- LOW inflammatory and no specific oxidative DNA damage: no specific
BiOLinkMatrix Natural tissue Bio-stimulation
Hallura@’s HA collection stimulated the extracellular matrix by
enhancing the elastin and collagen networks.
BIOENIX, Study report: Comparing dermal fibroblast responses after 48hrs of exposure to two hyaluronic acid dermal fillers with distinct cross-linking agents: An in vitro study. Host (fibroblasts) response to the dermal filler used in the test.
BioEC study reports – 22E5696, 22E5830. Elastin and Collagen I stimulation 7 days post injection in a Human skin explant.
COLLAGEN GENERATION
Hallura gels are more than a filler: Fibroblasts stimulated by HLR gels produce new collagen and elastin more effectively.
Human fibroblast culture in presence of HLR-21
Natural tissue Bio-stimulation²
Hallura’s HA collection stimulates the extracellular
matrix by enhancing the elastin and collagen networks.
(1) BIOENX, Study report: Comparing dermal fibroblast responses after 48hrs of exposure to two
(2) BioEC study reports – 22E5696, 22E5830 Elastin and Collagen I stimulation 7 days post injection in a Human skin explant.
HALLURA® Vs
COMPETITORS
BiOLinkMatrix – Clinical data demonstrates Best in Class Efficacy
Compared to the USUal observations made in clinical studies of the best products on the market
HALLURA European Clinical Study (19E2031), prospective, interventional, non-randomized, multi-centers, open-label study, on 132 patients for Lips enhancement, NLF correction and Cheeks enhancement. Compared to FDA, pivotal studies data on Market leaders.
Tissue Integration
Hallura ensures excellent tissue integration through its innovative technology, fostering seamless and natural assimilation with the body’s own tissue. This results in enhanced aesthetic outcomes, providing a harmonious blend for a more natural and radiant appearance.
- Superior Tissue Integration:
Hallura excels in tissue integration, surpassing market leaders. Our technology minimizes the risk of foreign-body reactions, fostering a seamless and natural process.
- Long-Term Safety Assurance:
With high potential for superior long-term safety, Hallura’s advanced technology reduces the likelihood of adverse reactions, ensuring sustained well-being for our patients.
- Natural Ingrowth Over Time: The unique composition of BiOLinkMatrix favors natural tissue ingrowth, promoting a gradual and harmonious integration with surrounding tissues for enduring and natural results.
BioLinkMatrix
12 Months Follow-Up demonstrates very high satisfaction from patients and physicians
SUBJECTS
Global Aesthetic Improvement – Subjects
EVALUATORS
Global Aesthetic Improvement – Independent Live Evaluators
80% of subjects and Independent Live Evaluators see improvement over 12 months
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FAQ
Most frequent questions and answers
Hallura’s BiOLinkMatrix is an innovative technology that redefines the landscape of hyaluronic acid (HA) dermal fillers. It employs a unique “lock-key” cross-linking method, providing perfectly elastic results compared to current HA fillers in the market.
Traditional HA fillers are often cross-linked using methods that may result in reduced natural elasticity. Hallura’s BiOLinkMatrix, on the other hand, preserves the long polymer chains, ensuring pure elasticity for a more natural and youthful appearance.
Hallura’s advanced product line includes treatments for skin rejuvenation, fine and deep line smoothing, as well as volume restoration in lips and mid-face. Our products have undergone rigorous pre-clinical and clinical trials in Europe, demonstrating excellent efficacy and safety outcomes.
Hallura’s commitment to safety is rooted in its use of bio-orthogonal chemistry, allowing for exceptionally low modification of native HA polymer during the cross-linking process. This preserves the innate properties of the biopolymer, ensuring safety and natural outcomes.
Hallura has successfully conducted multi-site clinical trials in Europe, demonstrating excellent performance and safety across various facial treatment indications. The results indicate the potential of BioLinkMatrix gels to reduce post-treatment reactions and meet the demand for effective and better-tolerated aesthetic treatments.
For inquiries or to schedule a consultation, you can contact us through email at hallura@hallura.com. We value fast and efficient support, ensuring a smooth experience for our clients.
Hallura’s aesthetic treatments are designed to deliver long-lasting results. The duration can vary based on the specific treatment and individual factors, but our commitment is to provide results that stand the test of time.
Preserving long chains in Hallura’s technology is crucial for maintaining the natural elasticity of hyaluronic acid (HA). This unique approach enhances the effectiveness of our dermal fillers for skin rejuvenation.
Hallura’s technology fosters bio-stimulation of collagen by promoting the natural production of collagen types 1 and 3. This contributes to skin rejuvenation, providing long-lasting and natural-looking results.
Hallura’s commitment to preserving the innate properties of the biopolymer, such as long polymer chains, ensures a natural look and feel in our dermal fillers. This focus on purity and elasticity distinguishes Hallura from other products.
Our HA Fillers provide superior, lasting beauty.
Join us for a new standard in aesthetics.
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Contact Us
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Phone
+972 4 8550240
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Email
info@hallura.com